Fabrazyme is used to treat patients with Fabry disease. Fabrazyme lowers the amount of a substance called globotriaosylceramide (GL-3), which builds up in cells lining the blood vessels of the kidney and certain other cells.
The lowering of GL-3 suggests that Fabrazyme may improve how Fabry disease affects your body; however, a relationship of lower GL-3 to specific signs and symptoms of Fabry disease has not been proven.
How Fabrazyme Works
See how Fabrazyme works inside the body
Fabrazyme helps patients with Fabry disease by replacing a missing enzyme. Watch this video to learn how Fabrazyme works inside the body.
Learn more about Fabry
disease and treatment
What to Expect From Treatment
Preparing for your infusion
Your first infusion of Fabrazyme will be given in a doctor’s office or an infusion center. After several infusions, your doctor may give you the option of receiving Fabrazyme in your home.
To better incorporate infusions into your life, you may be able to request a specific day and/or time for your treatment. It is also a good idea to arrange for transportation to and from the infusion site—especially on your first visit.
Before you have your infusion, you may have an assessment by a healthcare professional, which can include asking you how you are currently feeling, measuring your weight, your heart rate, blood pressure, and temperature. Next, you may be given anti-fever (such as acetaminophen or ibuprofen) and antihistamine medications to help prevent or reduce infusion-associated reactions.
Following the assessment, the healthcare professional will start your IV, either through your port or through a vein in your arm. This is how Fabrazyme will get into your body during the infusion.
The most common side effects reported with Fabrazyme are infusion-associated reactions. Some reactions were severe. Infusion-associated reactions occurred in 59% of patients but tended to decline in frequency with continued use of Fabrazyme during clinical studies. However, infusion-associated reactions may still occur despite extended duration of Fabrazyme treatment.
Some people may need to take anti-fever and antihistamine medications right before their infusion. Infusion-associated reactions have happened in some people even after taking these medications and steroids before their infusions.
If an infusion-associated reaction occurs, symptoms may be improved by slowing the infusion rate, stopping the infusion for a short time, giving more anti-fever and antihistamine medications and/or steroids.
If severe infusion-associated reactions happen, your doctor should consider stopping the infusion right away and provide medical care for your condition. Because severe infusion-associated reactions may happen, medical support and treatment should be readily available during your infusion.
Read about what to
expect before, during,
and after your infusion